![]() In the in vivo LM2-4 model, VT monotherapy had no effect on primary tumors, but significantly delayed distant metastatic dissemination to the lungs. In mice, VT treatment inhibited the transit of TCs through the pulmonary endothelium, but not the hepatic or lymphatic endothelium. In vitro, VT and Ang1 treatments impeded endothelial hypermeability and the transendothelial migration of MDA-MB-231∙LM2-4 (breast), HT29 (colon), or SN12 (renal) cancer cells to varying degrees. We hypothesized that systemic therapy with Vasculotide (VT)-a purported Ang1 mimetic, Tie2 agonist-can reduce the extravasation of potentially metastatic circulating TCs by similarly stabilizing the host vasculature. Specifications and documentation subject to change without notice.Angiopoietin-1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. Motorized Iris with Variable Pulse EffectsĦ Dichroic Colors including High CRI Filter and UVĦ Rotating / Indexing Interchangeable Glass Gobosįull Color 180° Reversible LCD Menu Displayįor current update please provide your current software version Internal Color, Framing, Prism, and Frost Macros Motorized Zoom (Large 180mm Front Aperture)Ģ Variable Frost Filters (Light and Wash) *May vary depending on several factors including but not limited to:Įnvironmental Conditions, Power/Voltage, Usage Patterns (On-Off Cycling), Control, and Dimming. Proteus Maximus - Photometric Test Report Proteus Maximus - Important Technical Information ![]() Wide Zoom Range from 5.5° to 55° / Large 180mm Front ApertureįIL (Foam In Lay) Polyurethane Foam Packaging Included ![]() High Efficiency 950W 6,500K White LED EngineĦ Position Color Wheel, High CRI, UV filterĬomplete FX System featuring Rotating and Fixed Gobos, Animation, Iris, Dual Prism, Dual Frost This foam insert easily fits into a custom sized flight case (not included), and provides enhanced impact protection during transport. ![]() ![]() The PROTEUS MAXIMUS fixture ships in a cardboard box with a custom fitted polyurethane foam FIL (Foam In Lay) insert. With a fast zoom range from 5.5° to 55° and an impressive 180mm front lens the Proteus Maximus has the power to cut through at great distances in any outdoor concert, special events and with its fully dust and water proof design it is an ideal fixture for theme parks and cruise ships. Its indexable framing system provides full blackout shutter cuts for precise beam shape control. Proteus Maximus provides the designer a comprehensive FX package with 6 rotating and 7 fixed glass gobos, full animation wheel, dual prisms, dual frost and a high-speed Iris. Providing up to 50.000 lumens from its custom designed 950W 6,500K LED engine the Proteus Maximus is the ideal fixture for any outdoor application requiring superior output, bright and powerful beams, quiet operation as well as stunningly precise gobos and colors. The PROTEUS MAXIMUS™ an extremely bright IP65 rated LED Profile fixture offering outstanding projection, beam and wash qualities in any environment. ![]()
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